Īge: Usually between 6 months and 4 years of age.This IgG antibody probably recognizes shared viral and erythroid progenitor epitopes. On the basis of these observations, it has been speculated that a non-specific virus is cleared as the host develops IgG antibody. Ĭellular inhibitors of erythropoiesis: Inhibitory mononuclear cells have been observed in approximately 25% of patients with TEC.Serum inhibitors of erythropoiesis: IgG inhibitors of normal progenitor cells have been found in 60–80% of patients with TEC. ĬFU-E and BFU-E: Both are decreased in 30–50% of patients, suggesting that the defect might be at the CFU-E and BFU-E levels.Įrythropoietin levels: Serum erythropoietin levels are high, in keeping with the degree of anemia.Viral: There is usually a history of a preceding non-specific viral illness 1–2 months prior to TEC. Pathophysiology: The following clinical and laboratory observations have shed light on the basic mechanisms of the pathogenesis of TEC: TEC is much more common than DBA and must be differentiated from DBA ( Table 8.14), in order to avoid unnecessary corticosteroid use. There are no long-term hematologic sequelae of TEC, and recurrences are rare. RBC transfusion may be required to treat symptomatic anemia, but steroid therapy is unnecessary and not effective. The natural history of TEC is one of spontaneous recovery over a period of several weeks, and because most children are recognized at the nadir of their anemia, evidence of recovery may already be present. The abnormal RBC features seen in DBA are not seen in TEC. The platelet count sometimes is increased, and neutropenia may be present ( Rogers et al, 1989). As in DBA, the hallmarks of the disorder are anemia and reticulocytopenia, with an absence of erythroid precursors in the bone marrow. Evidence of a humoral or cellular immune response directed against erythroid precursor cells has been obtained in many affected children. TEC is an acquired hypoplastic anemia that usually appears several weeks after an acute viral infection ( Wranne, 1970). Glader, in Avery's Diseases of the Newborn (Eighth Edition), 2005 Transient Erythroblastopenia of Childhood
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